目的 研究枇杷叶药渣中三萜酸类成分的最佳提取工艺条件。方法 采用单因素分析和正交实验设计法，选择乙醇浓度(A)、料液比(B)、提取时间(C)、提取次数(D)为因素各取3水平，按L₉(3⁴)正交表进行实验。结果 乙醇浓度为主要因素、提取次数为次要因素。其最佳工艺条件为A₂B₁C₃D₁，即7倍量90%的乙醇，80 ℃加热回流2次，每次1.5 h。结论 以乙醇为溶剂提取枇杷叶药渣中三萜酸类成分效果较好，本实验为医药生产企业综合利用枇杷叶资源提供了有用信息。

OBJECTIVE To study the optimum extraction condition of triterpene acids in ldregs of leaves of Eriobotrya japonica (Thunb.) Lindl. METHODS Single factor analysis and orthogonal experimental design were used to select the concentration of ethanol (A), solid-liquid ratio (B), extraction time (C), and extraction times (D) by L₉(3⁴) orthogonal test. RESULTS The concentration of ethanol was the main process factor, and extraction times was the secondary factor. The optimum condition was A₂B₁C₃D₁, which included using 90% ethanol as the extraction solvent with 7 times the amount of φ, and 80 ℃ heat back for 2 times, 1.5 h for each time. CONCLUSION Ethanol has good extraction effect for triterpene acids in loquat residue. This study provides important information for the comprehensive utilization of leaves of Eriobotrya japonica (Thunb.) Lindl. resources by pharmaceutical manufacturers.